Presentation and diagnosis Transfusion-associated graft versus host disease

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1 presentation , diagnosis

1.1 clinical manifestations
1.2 laboratory manifestations
1.3 diagnosis





presentation , diagnosis
clinical manifestations

the clinical presentation same gvhd occurring in other settings, such bone marrow transplantation. ta-gvhd can develop 4 thirty days after transfusion. typical symptoms include:





fever
erythematous maculopapular rash, can progress generalised erythroderma
toxic epidermal necrolysis in extreme cases



other symptoms can include cough, abdominal pain, vomiting, , profuse diarrhea (up 8 liters/day).


laboratory manifestations

laboratory findings include pancytopenia, abnormal liver enzymes, , electrolyte imbalance (when diarrhea present).


diagnosis

ta-gvhd can suspected biopsy of affected skin, , established hla analysis of circulating lymphocytes. testing can identify circulating lymphocytes different hla type tissue cells of host.







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