Society and culture Rho(D) immune globulin
1 society , culture
1.1 manufacturing , safety
1.2 routes of administration
1.3 names
society , culture
manufacturing , safety
rho(d) immune globulin derivative of human plasma. common way anti-d products manufactured form of cohn cold ethanol fractionation method developed in 1950s. variations of cohn method developed in 1950s may not clear aggregates of immunoglobulins, can cause problems patients if administered intravenously, , primary reason why anti-ds intramuscular use only. non-cohn manufacturing variation chromaplus process approved u.s. food , drug administration (fda) used make rhophylac. rho(d) immune globulin may trigger allergic reaction. steps taken in plasma-donor screening process , manufacturing process eliminate bacterial , viral contamination, although small, residual risk may remain contamination small viruses. there theoretical possibility of transmission of prion responsible creutzfeldt–jakob disease, or of other, unknown infectious agents.
routes of administration
rhig can administered either either intramuscular (im) or intravenous (iv) injection, depending on preparation. im-only preparation should never administered iv due risk of complement system activation. multiple im doses should given @ different sites or @ different times within 72-hour window. or, multiple iv doses can administered according instructions in package insert.
names
rho(d) immune globulin spelled rh0(d) immune globulin (letter o , digit 0 both attested; more @ rh blood group system - rh nomenclature.
rhophylac manufactured csl limited. rhogam , micrhogam brand names of kedrion biopharma. other brand names bayrho-d, gamulin rh, hyprho-d mini-dose, mini-gamulin rh, partobulin sdf (baxter), rhesonativ (octapharma), , rhesugam (nbi). kamrho-d i.m. brand name of kamada ltd.
the united states distribution rights winrho sdf (another brand name) transferred baxter manufacturer, cangene, in 2010; had been held baxter since 2005. sales of winrho fell every year under agreement baxter, supposition being baxter favoring sale of own product on winrho; according 1 analyst, winrho afterthought big company baxter.
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