Structure and activity Salbutamol

-


(r)-(−)-salbutamol (top) , (s)-(+)-salbutamol (bottom)


salbutamol sold racemic mixture. (r)-(−)-enantiomer (cip nomenclature) shown in image @ right (top), , responsible pharmacologic activity; (s)-(+)-enantiomer (bottom) blocks metabolic pathways associated elimination of , of pharmacologically active enantiomer (r). slower metabolism of (s)-(+)-enantiomer causes accumulate in lungs, can cause airway hyperreactivity , inflammation.








Comments

Post a Comment

Popular posts from this blog

Memorial Series Board Lutfuddaulah Oriental Research Institute

-
1 memorial series board 1.1 president 1.2 members 1.3 secretary , treasurer memorial series board president chief justice, nawab jiwan yar jung bahadur, b.a., (cantab.) bar-at-law. members justice, nawab alam yar jung bahadur, m. a., ll.b,. bar-at-law (oxon.). justice, nawab asghar yar jung bahadur, b.a., (oxon.) bar-at-law. rai wittinal rai, member, executive committee,. paigah of nawab lutf ud-dawlah bahadur. sayyid ahmedullah qadri. secretary , treasurer sayyid sa ad-ullah qadri. ^ full text of life being autobiography of nawab server-ul-mulk bahadur . archive.org. 1929-02-24. retrieved 2015-10-08.  ^ full text of calendar 1348 1351 fasli . archive.org. retrieved 2015-10-08.  ^ cite error: named reference archive1 invoked never defined (see page).
Read more

Weak verbs Proto-Germanic grammar

-
1 weak verbs 1.1 suffixless weak verbs 1.2 class 1 1.3 class 2 1.4 class 3 1.5 class 4 weak verbs weak verbs used suffix containing dental consonant mark past tense. suffix held reflex of reduplicated past imperfect of pie *dheh1- put , in germanic . derived verbs, being formed nouns, verbs or adjectives (so-called denominal, deverbal , deadjectival verbs). few underived verbs strong j-present verbs acquired weak past tenses in proto-germanic. weak verbs divided 5 main classes, of 4 survived distinct history of daughter languages. 1 class formed few relic verbs have no present-tense suffix, verbs in other classes had present-tense suffix, varied class class. past tense endings identical, , resembled of strong verbs, prefixed dental infix. follows: the initial consonant of suffix -d-, class 1 j-present verbs, suffixless weak verbs , preterite-present verbs had -t- if ending consonant of stem obstruent, in case obstruent assimilated dental. suffixless weak verbs already small relic cla...
Read more

History Anthrax

-
1 history 1.1 etymology 1.2 discovery 1.3 first vaccination history etymology the english name comes anthrax (ἄνθραξ), greek word coal, possibly having egyptian etymology, because of characteristic black skin lesions developed victims cutaneous anthrax infection. central, black eschar, surrounded vivid red skin has long been recognised typical of disease. first recorded use of word anthrax in english in 1398 translation of bartholomaeus anglicus work de proprietatibus rerum (on properties of things, 1240). anthrax has been known wide variety of names, indicating symptoms, location , groups considered vulnerable infection. these include siberian plague, cumberland disease, charbon, splenic fever, malignant edema, woolsorter s disease, , la maladie de bradford. discovery robert koch, german physician , scientist, first identified bacterium caused anthrax disease in 1875 in wolsztyn (now part of poland). pioneering work in late 19th century 1 of first demonstrations diseases caused mic...
Read more