Diagnosis Primary central nervous system lymphoma

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micrograph showing primary cns lymphoma characteristic perivascular distribution composed of large cells prominent nucleoli. brain biopsy. hps stain.


the definitive diagnosis arrived @ tissue, i.e. biopsy, pathologist.


mri or contrast enhanced ct classically shows multiple ring-enhancing lesions in deep white matter. major differential diagnosis (based on imaging) cerebral toxoplasmosis, prevalent in aids patients , presents ring-enhanced lesion, although toxoplasmosis presents more lesions , contrast enhancement typically more pronounced. imaging techniques cannot distinguish 2 conditions certainty, , cannot exclude other diagnoses. thus, patients undergo brain biopsy.







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