Methods Ablative brain surgery




1 methods

1.1 sham lesions
1.2 excitotoxic lesions
1.3 radio frequency lesions





methods

experimental ablation involves drilling of holes in skull of animal , inserting electrode or small tube called cannula brain using stereotaxic apparatus. brain lesion can created conducting electricity through electrode damages targeted area of brain. likewise, chemicals can inserted in cannula possibly damages area of interest. comparing prior behavior of animal after lesion, researcher can predict function of damaged brain segment. recently, lasers have been shown effective in ablation of both cerebral , cerebellar tissue. laser technology called mri-guided laser ablation, example, allows great precision in location , size of lesion , causes little no thermal damage adjacent tissue. texas children s hospital 1 of first use mri guided method destroy , treat brain lesions , precisely. prime example patient @ hospital no longer undergoes frequent seizures because of success of treatment. mri-guided laser ablation used ablating brain, prostate , liver tumors. heating or freezing alternative methods ablative brain surgery.


sham lesions

a sham lesion way researchers give placebo lesion animals involved in experimental ablation. whenever cannula or electrode placed brain tissue, unintended additional damage caused instrument itself. sham lesion placement of lesioning instrument same spot placed in regular lesion, there no chemical or electrical process. technique allows researchers compare appropriate control group controlling damage done separate intended lesion.


excitotoxic lesions

an excitotoxic lesion process of excitatory amino acid being injected brain using cannula. amino acid used kill neurons stimulating them death. kainic acid example of excitatory amino acid used in type of lesion. 1 crucial benefit lesion specificity. chemicals selective in don t damage surrounding axons of nearby neurons, target neurons.


radio frequency lesions

radio frequency (rf) lesions produced electrodes placed in brain tissue. rf current alternating current of high frequency. process during current passes through tissue produces heat kills cells in surrounding area. unlike excitotoxic lesions, rf lesions destroy in nearby vicinity of electrode tip.


the use of ablative brain surgery on nucleus accumbens wrong method treat addictions according dr. charles o’brien. dr. john adler ignoring nuremberg code, believes ablation can provide valuable information how nucleus accumbens works.








Comments

Popular posts from this blog

Memorial Series Board Lutfuddaulah Oriental Research Institute

Weak verbs Proto-Germanic grammar

History Anthrax