Synthesis Midodrine



α-adrenergic agonist. prepn: see also:



acylation of 1,4-dimethoxybenzene chloroacetyl chloride gives chloroketone 2. halogen converted amine 3 set of standard schemes, , ketone reduced alcohol borohydride (4). acylation of amino group in last intermediate chloroacetyl chloride affords amide 5. halogen displaced azide , resulting product 6 reduced catalytically glycinamide, midodrine (7).








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