Gene regulation ADP-ribosylation

crystal structure of parp1 zinc finger domain bound dna (purple). pdb: 4av1

parps have been shown affect transcription factor structure , cause recruitment of many transcription factors form complexes @ dna , elicit transcription.mono adp-ribosyltransferases shown affect transcription factor binding @ promoters. example, parp14, mono adp-ribosyltransferase, has been shown affect stat transcription factor binding.

other adp-ribosyltransferases have been shown modify proteins bind mrna, can cause silencing of gene transcript.